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Both PIM2 and HKII expression is high in breast cancer cells, resulting in enhanced glycolysis and cellular growth, which has been associated with paclitaxel resistance [105]

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Glutathionylation of the active site cysteine, a prerequisite for enzymatic activity, occurs only under highly oxidizing conditions established by the GSH/glutathione disulfide (GSSG) redox couple, while class I GRXs are readily glutathionylated even at very negative GSH/GSSG redox potentials